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Prolactin data observed were similar between INVEGA HAFYERA® and INVEGA TRINZA®1
Percentage of patients in the pivotal study with increased prolactin levels relative to maintenance baseline
Hyperprolactinemia: Like other drugs that antagonize dopamine D2 receptors, paliperidone elevates prolactin levels, and the elevation persists during chronic administration. Paliperidone has a prolactin-elevating effect similar to that seen with risperidone, a drug that is associated with higher levels of prolactin than other antipsychotic drugs.
Percentage of patients in the pivotal study with potentially prolactin-related adverse reactions
Reference: 1. INVEGA HAFYERA® [Prescribing Information]. Titusville, NJ: Janssen Pharmaceuticals, Inc.