FOR US HEALTHCARE PROFESSIONALS ONLY
Speaker 1:
Navigating Long-Acting Injectable Conversations to Achieve Longer Dosing Intervals in Adult Patients With Schizophrenia, a virtual national broadcast for pharmacists in mental health. This video was developed from virtual sessions previously recorded in June 2022. Any audience participation and/or interactivity will not be enabled or be available as part of this presentation. Our guest speaker is Dr. Alberto Augsten, pharmacy clinical manager and board-certified clinical toxicologist at Memorial Regional Hospital in Hollywood, Florida.
Alberto Augsten:
As Mary said, let's go ahead and begin this very interesting discussion on navigating long-acting injectable conversations to achieve longer dosing intervals in adult patients with schizophrenia. So once again, thank you and welcome to the program. It must be stated, this is a promotional educational activity brought to you by Janssen. It's not certified for continued medical education. I'm a paid speaker for Janssen, and we're presenting on behalf of Janssen and must present information in compliance with the FDA.
Now, let's educate ourselves with something related to the schizophrenia relapse cycle. We're going to be looking at this particular data that comes from some market research of over 620 patient chart reviews. And when they looked at this data, when Janssen looked at this data, we looked at on average, patients are treated with four different oral antipsychotic regimens before starting the LAI. And let's go ahead and describe what you're seeing in front of you.
What you see here is this blue diagram, and I call it the little rollercoaster of multiple relapses. You have multiple little red dots, and at the beginning of the initiation of this rollercoaster, you have average age of onset of schizophrenia—early twenties in males, early twenties to early thirties in females. First schizophrenia diagnosis, then you have an initiation of an oral antipsychotic regimen. Then you have this up and down, up and down, with multiple relapses—an average of nine times over the course of 5.5 years—with four different oral regimen initiations and switches before you get to the end, where you have your first LAI initiation, first start, at the average age of 38 years of age.
Now, I know that many of us here, and many of us that have been practicing for many years, have seen this. We've seen this with our own eyes. We can relate, saying this patient has probably been admitted multiple times, or they're in our particular setting. But now you have data to support that saying that you have an average of four different oral regimens before your first LAI start of 38 years of age. And this should resonate with you. You're probably asking the question, "Why? Why are we delaying the time to start of the LAI for so long?"
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